在胰岛素依赖性糖尿病(IDDM)早期,胰岛抗体(ICA)和胰岛细胞表面抗体(ICSA)检出率甚高,此提示其发病与免疫机理有关。因为Grave病、慢性甲状腺炎、阿迪森病、恶性贫血是一些器官特异性的自身免疫性疾病,IDDM合并这些自身免疫性疾病并不罕见。此外,在IDDM发病早期常可检出 In the early stage of insulin-dependent diabetes mellitus (IDDM), the detection rate of islet antibody (ICA) and islet cell surface antibody (ICSA) is very high, which suggests that its pathogenesis is related to the immune mechanism. Because Grave’s disease, chronic thyroiditis, Addison’s disease, and pernicious anemia are some organ-specific autoimmune diseases, it is not uncommon for IDDM to incorporate these autoimmune diseases. In addition, IDDM can often be detected early in the onset