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目的:观察淫羊藿对去卵巢大鼠胫骨干骺端骨计量学参数的影响。方法:雌性 Wistar 大鼠随机分成假手术组、去卵巢组、尼尔雌醇组和淫羊藿组。除假手术组外,其余各组切除卵巢制备绝经后骨质疏松模型,对尼尔雌醇组和淫羊藿组分别治疗3个月。用骨计量学方法研究去卵巢大鼠胫骨干骺端对淫羊藿的治疗反应。结果:淫羊藿组骨密度比去卵巢组明显增加;骨计量学研究表明:与去卵巢组相比,淫羊藿组骨小梁体积/全部骨组织体积(TBV/TTV)、骨小梁体积/海绵骨体积(TBV/SBV)、平均骨小梁板厚度(MTPT)显著增加(P<0.05),骨小梁表面与其体积之比(S/V)、平均骨小梁板间隙(MTPS)和骨小梁类骨质表面占骨小梁表面的百分比(TOS)明显减少(P<0.05),平均类骨质宽度(MOSW)、四环素双标记线间的平均距离(DDL)、矿化沉积率(MiAR)和组织水平的骨沉积率(Svf)有增加趋势(P>0.05)。结论:淫羊藿不明显改变骨转换,但减少骨吸收,具有一定程度的刺激骨形成和增加骨量的作用。
OBJECTIVE: To observe the effects of Epimedium on the metrological parameters of tibial metaphysis in ovariectomized rats. Methods: Female Wistar rats were randomly divided into sham group, ovariectomized group, nilestriol group and epimedium group. Except for the sham-operated group, the rest of the groups were ovariectomized to prepare the postmenopausal osteoporosis model, and the nilestriol group and epimedium group were treated for 3 months. The bone resorption response to epimedium was studied using bone metrology in ovariectomized rats. RESULTS: Bone mineral density was significantly increased in the epimedium group compared with the ovariectomized group. Bone histomorphometric studies showed that the epimedium group had trabecular volume/total bone tissue volume (TBV/TTV) and trabecular bone compared with the ovariectomized group. Volume/sponse bone volume (TBV/SBV), mean bone plate thickness (MTPT) increased significantly (P<0.05), ratio of trabecular surface to volume (S/V), mean trabecular plate space (MTPS) Significant reduction in percentage (TOS) of trabecular bone surface and trabecular bone surface (P<0.05), mean bone mass width (MOSW), mean distance between double lines of tetracycline (DDL), and mineralization The deposition rate (MiAR) and tissue-level bone deposition rate (Svf) increased (P>0.05). CONCLUSION: Epimedium does not significantly alter bone turnover, but it decreases bone resorption and has a certain degree of stimulatory effect on bone formation and bone mass.