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目的:观察补肾抗风湿方药-寒痹康汤对胶原诱导性关节炎(CIA)大鼠血清血管内皮生长因子(VEGF)的影响。方法:采用牛Ⅱ型胶原蛋白和弗氏不完全佐剂诱导CIA大鼠模型,以甲氨蝶呤为对照,观察不同剂量寒痹康汤对CIA大鼠的关节肿胀指数以及血清VEGF水平的影响。结果:寒痹康汤各剂量组大鼠的关节肿胀指数及升高的VEGF水平均降低(P<0.01),其中中剂量寒痹康汤作用与甲氨蝶呤组相当(P>0.05),高剂量寒痹康汤作用优于甲氨蝶呤(P<0.01)。结论:补肾抗风湿方药-寒痹康汤可以通过降低CIA大鼠血清VEGF水平而达到治疗类风湿关节炎的作用。
Objective: To observe the effect of Bushen anti-rheumatism recipe - Hanbi Decoction on serum vascular endothelial growth factor (VEGF) in rats with collagen-induced arthritis (CIA). Methods: CIA rats were induced by bovine type Ⅱ collagenase and incomplete Freund’s adjuvant. Methotrexate was used as control to observe the effects of different doses of Hanbi Decoction on joint swelling index and serum VEGF in CIA rats . Results: The joint swelling index and the elevated VEGF level of each group of Hanbokang decoction were decreased (P <0.01), and the effect of Hanbiekang decoction was similar to that of methotrexate group (P> 0.05) High-dose Hanbi Decoction better than methotrexate (P <0.01). Conclusion: Bushen anti-rheumatic prescription - Hanbi Decoction can reduce rheumatoid arthritis of CIA rats to achieve the effect of treatment of rheumatoid arthritis.