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用放射免疫法测定111例急性肝炎、慢性肝炎、肝硬化患者血清透明质酸（HA）、Ⅲ型前胶原（HPCⅢ）、层粘蛋白（LN）含量。结果发现：与健康对照组比较，各肝病组血清HA、LN含量均明显升高，差异有极显著统计学意义（P＜0．001）。急性肝炎组患者血清HPCⅢ含量较正常对照组无明显升高，差异无显著统计学意义（P＞0．05）。而慢性肝炎组和肝硬化组HPCⅢ含量较正常组明显升高，差异有极显著统计学意义（P＜0．001）。
The contents of hyaluronic acid (HA), type Ⅲ procollagen (Ⅲ) and laminin (LN) in 111 patients with acute hepatitis, chronic hepatitis and cirrhosis were determined by radioimmunoassay. The results showed that compared with the healthy control group, the serum levels of HA and LN in each liver disease group were significantly increased, the difference was statistically significant (P <0.001). Serum HPCⅢlevels in acute hepatitis group were not significantly higher than those in normal control group, with no significant difference (P> 0.05). However, the levels of HPCⅢ in chronic hepatitis group and cirrhosis group were significantly higher than those in normal group, the difference was statistically significant (P <0.001).