左旋吡喹酮250mg/kg和417mg/kg灌胃一次治疗人工感染血吸虫小鼠、减虫率分别为50.0%和71.9%.右旋吡喹酮用上述两种同样剂量灌胃一次治疗感染小鼠,减虫率分别为-5.9%和4.3%,几无抗虫作用.吡喹酮衍生物S-01、S-02和S-04分别用235.5mg/kg,qd×3d;233.0mg/kg,qd×3d和213.8mg/kg,qd×3d(均为0.64mmol/kg/d×3d)治疗感染小鼠,减虫率分别为10%、6%和12%,该三种衍生物抗虫作用均较吡喹酮差. L-praziquantel 250mg / kg and 417mg / kg intragastric administration of artificial infection of Schistosoma japonicum mice, the worm reduction rates were 50.0% and 71.9% .D-praziquantel with the same two doses of the above-mentioned treatment of infected mice , And the worm reduction rates were -5.9% and 4.3%, respectively, and there was almost no anti-insect effect. Praziquantel derivatives S-01, S-02 and S-04 were treated with 235.5mg / kg qd × 3d and 233.0mg / kg , qd × 3d and 213.8 mg / kg, qd × 3d (both 0.64 mmol / kg / d × 3d), the worm reduction rates were 10%, 6% and 12% Insect effect than praziquantel worse.