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目的：探讨还原型谷胱甘肽治疗肝病的疗效和安全性。方法：２９５例肝病病人，男性２２９例，女性６６例，年龄（４４±１２ 岁）。用谷胱甘肽注射液１２００ｍｇ加入５％葡萄糖液２５０ｍｌ中静滴，ｑｄ × ３ｗｋ为一个疗程（用１～３个疗程）。结果：治疗前 ＡＬＴ、ＡＳＴ、ＳＢ、ＴＧ、ＬＤＬ分别为２６０ＩＵ／Ｌ±３７５ＩＵ／Ｌ、２０６ＩＵ／Ｌ±３６０ＩＵ／Ｌ、１３２μｍｏｌ／Ｌ±１５９μｍｏｌ／Ｌ、３.０μｍｏｌ／Ｌ ±１．５ｍｍｏｌ／Ｌ和３．２ｍｍｏｌ／Ｌ±０．８ｍｍｏｌ／Ｌ。治疗３ｗｂ后依次为７３ＩＵ／Ｌ±７４ＩＵ／Ｌ、７６ＩＵ／Ｌ±８９ＩＵ／Ｌ、１０７μｍｏｌ／Ｌ± １６１μｍｏｌ／Ｌ、２．７ｍｍｏｌ／Ｌ±１．４ｍｍｏｌ／Ｌ、２．９ｍｍｏｌ／Ｌ±１．８ｍｍｏｌ／Ｌ。３ｗｋ时总有效率为７７．８％。６ｗｋ时８４．３％，９ｗｋ时 为８９．３％。不良反应轻微。结论：还原型谷胱甘肽是一安全有效的保肝药物。
Objective: To investigate the efficacy and safety of reduced glutathione in the treatment of liver disease. Methods: A total of 295 liver disease patients, 229 males and 66 females, aged 44 ± 12 years. Glutathione injection with 1200mg 5% glucose solution 250ml intravenous infusion, qd × 3wk for a course of treatment (with 1 to 3 courses). Results: Before treatment, ALT, AST, SB, TG, LDL were 260IU / L ± 375IU / L, 206IU / L ± 360IU / L, 132μmol / L ± 159μmol / L, 3.0μmol / L ± 1.5mmol / L And 3.2 mmol / L ± 0.8 mmol / L. After 3 weeks of treatment, they were 73IU / L ± 74IU / L, 76IU / L ± 89IU / L, 107μmol / L ± 161μmol / L, 2.7mmol / L ± 1.4mmol / L, 2.9mmol / L ± 1.8mmol / L. 3wk total effective rate of 77.8%. 84.3% at 6wk, and 89.3% at 9wk. Minor adverse reactions. Conclusion: Reduced glutathione is a safe and effective hepatoprotective drug.