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钙拮杭剂(Ca~(++)-An)即钙通道阻滞剂,它能选择性阻断病理状态下细胞膜的钙通道,防止Ca~(++)进入细胞内。还可阻止细胞内贮存Ca~(++)的释放,以防止细胞内Ca~(++)([Ca~(++)]_i)过量造成损伤。但一般不影响生理情况下Ca~(++)的内稳定性。它是一类新型的平滑肌松弛剂。自1963年发现后,主要用于治疗心血管疾病。1976年以来于实验和临床相继证实此类药物对脑损伤有保护作用。现将有关资料综述如下。一、Ca~(++)-An的种类 (一)根据作用的器官与强度 1.对脑血管作用较明显的Ca~(++)-An: Nimodipine、硝苯苄胺啶(Nicardipine)、脑益嗪(Cinnarizine)、氟苯桂嗪(Flunarz-ine)、Gallopamil。
Calcium antagonists (Ca ~ (++) - An) is a calcium channel blocker that selectively blocks the calcium channels in the cell membrane in pathological conditions and prevents Ca ~ (++) from entering the cells. But also prevent the release of intracellular Ca ~ (++) to prevent the excessive intracellular Ca ~ (++) ([Ca ~ (++)] _i) injury. But generally does not affect the physiological conditions of Ca ~ (++) internal stability. It is a new type of smooth muscle relaxant. Since its discovery in 1963, it is mainly used for the treatment of cardiovascular diseases. Since 1976, it has been confirmed experimentally and clinically that such drugs have a protective effect on brain injury. The relevant information is summarized below. First, the Ca ~ (++) - An species (a) according to the role of organs and intensity of 1 on the role of cerebral vascular more obvious Ca ~ (++) - An: Nimodipine, nifedipine (Nicardipine) Cinnarizine, Flunarzine, Gallopamil.