肝纤维化是继发于肝脏炎症或损伤后组织修复过程中的代偿性反应,也是向肝硬化发展的主要中间环节,细胞外基质(ECM)在肝内过量沉积是其病理特征。肝纤维化最终可发展为肝硬化甚至肝癌[1],对晚期肝纤维化惟一有效的治疗方法是肝移植。有研究表明[2],肝纤维化有逆转的可能性。近年 Hepatic fibrosis is a compensatory reaction secondary to the tissue repair after inflammation or injury of the liver, and is also a major intermediate link to the development of cirrhosis. Excessive deposition of the extracellular matrix (ECM) in the liver is a pathological feature. Liver fibrosis eventually develops into cirrhosis and even liver cancer [1]. The only effective treatment for advanced liver fibrosis is liver transplantation. Some studies have shown [2], liver fibrosis reverse the possibility. in recent years