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在许多组织增生过程中 ,通过内分泌、旁分泌和自分泌会产生胰岛素样生长因子 1(IGF 1)。最近的研究发现 ,IGF 1存在于各种增生组织 ,如子宫内膜和卵巢组织。患有严重子宫内膜异位症时 ,血清中IGF 1水平较高 ,而子宫内膜局部的IGF 1水平减低 ,这可能是导致不孕的原因 ,多囊性卵巢综合征 (PCOS)患者卵巢局部的IGF 1活性增强 ,与患者肥胖、高雄激素水平等一系列临床症状有关。IGF 1在良、恶性肿瘤中也起着重要的作用 ,IGF 1能刺激子宫肌瘤细胞的生长。围绝经期妇女若存在高IGF 1和低IGF 1结合蛋白 3(IGFBP 3)水平 ,则患乳腺癌的风险增大。绝经前后女性的高IGF 1水平与宫颈癌、卵巢癌和子宫内膜癌的发病率存在相关性。
Insulin-like growth factor 1 (IGF1) is produced by endocrine, paracrine and autocrine during many tissue hyperplasias. Recent studies have found that IGF1 is present in a variety of proliferative tissues, such as endometrium and ovarian tissue. In patients with severe endometriosis, serum IGF-1 levels are elevated while endometrial IGF1 levels are reduced, which may be the cause of infertility in patients with polycystic ovarian syndrome (PCOS) Local IGF 1 activity increased, and the patient obesity, androgen levels and a series of clinical symptoms. IGF 1 also plays an important role in benign and malignant tumors, IGF 1 can stimulate the growth of uterine fibroids. Perimenopausal women have an increased risk of breast cancer if they have high IGF 1 and low IGF 1 binding protein 3 (IGFBP 3) levels. Premenopausal women with high IGF 1 levels and cervical cancer, ovarian cancer and the incidence of endometrial cancer there is a correlation.