目的系统评价TERC基因对宫颈高级别病变(≥CINⅡ)的诊断价值。方法计算机检索PubMed、EMbase、e Cochrane Library等数据库,检索时间截至2012年3月31日。按照纳入和排除标准筛选文献、提取资料并根据诊断性试验准确性质量评价工具(QUADAS)评价质量后,采用Meta-Disc 1.4软件进行Meta分析。结果最终纳入12篇文献,共7 894例患者。Meta分析结果显示:TERC基因诊断宫颈高级别病变的合并灵敏度、特异度和诊断比值比分别为0.81[95%CI(0.80,0.82)]、0.83[95%CI(0.82,0.84)]和17.37[95%CI(8.77,34.41)]。结论 TERC基因单独检测宫颈高级别病变的诊断价值中等,可作为临床诊断的一种辅助方法。 Objective To evaluate the diagnostic value of TERC gene in high-grade cervical lesions (≥CINⅡ). Methods The databases of PubMed, EMbase and e Cochrane Library were searched by computer. The search time was up to March 31, 2012. Meta-analysis was performed using Meta-Disc 1.4 software after screening the literature for inclusion and exclusion criteria, extracting data, and assessing quality according to the QUADAS (Quality of Diagnostic Tests) tool (QUADAS). The results eventually included 12 articles, for a total of 7 894 patients. The results of Meta analysis showed that the combined sensitivity, specificity and diagnostic odds ratio of TERC gene for diagnosis of high grade cervical lesions were 0.81 [95% CI (0.80,0.82)], 0.83 [95% CI (0.82,0.84)] and 17.37 [ 95% CI (8.77, 34.41)]. Conclusion The diagnostic value of TERC gene alone in the detection of high-grade cervical lesions can be used as an adjunct to clinical diagnosis.