As a basic problem in many engineering applications, transition from laminar to turbulence still remains a difficult problem in computational fluid dynamics (CFD). A numerical study of one transitional flow in two-dimensional is conducted by Reynolds averaged numerical simulation (RANS) in this paper. Turbulence model plays a significant role in the complex flows’ simulation, and four advanced turbulence models are evaluated. Numerical solution of frictional resistance coefficient is compared with the measured one in the transitional zone, which indicates that Wilcox (2006) k-ω model with correction is the best candidate. Comparisons of numerical and analytical solutions for dimensionless velocity show that averaged streamwise dimensionless velocity profiles correct the shape rapidly in transitional region. Furthermore, turbulence quantities such as turbulence kinetic energy, eddy viscosity, and Reynolds stress are also studied, which are helpful to learn the transition’s behavior.