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脱氧核糖核酸(DNA)修复合成试验或程序非DNA合成试验(unscheduled DNA synthesis assay,uds)是利用哺乳动物类细胞在体外预测化学物质致突变性和致癌性短时筛选方法之一。我们过去曾进行过“氮—氖激光对大鼠的致畸胎试验,“氦—氖激光对小鼠的显性致死效应”等实验,对氮—氖激光的致畸及生殖细胞染色体的影响进行了一些探讨。但是,氮—氖激光照射对大鼠外周血淋巴细胞DNA修复合成的影响或效应,国内尚未见到报道。为了对这一问题进行探索,我们于1984年8月进行了实验观察。结果如后:
DNA repair synthesis assays or procedures (unscheduled DNA synthesis assays, uds) are one of the short-term methods for predicting the mutagenicity and carcinogenicity of chemicals in vitro using mammalian cells. In the past, we conducted experiments on the teratogenicity of nitrogen-negative lasers in rats, and the “dominant lethal effect of deuterium-neon laser on mice”, and the effects on the teratogenicity and germ cell chromosomes of nitrogen-helium neon lasers. Some studies were conducted, but the effect or effect of nitrogen-helium neon laser irradiation on the DNA repair synthesis of rat peripheral blood lymphocytes has not yet been reported in China. In order to explore this issue, we conducted an experiment in August 1984. Observe the results as follows: