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目的 探讨氰化物对作业工人健康状况的慢性影响 ,了解尿硫氰酸盐 (USCN)浓度与症状、体征以及辅助检查指标的关系 ,验证USCN作为氰化物接触人群健康监护指标的有效性。方法 选取某石化企业 12 5名氰化物作业工人为研究对象 ,进行横断面调查 (主观症状、B超、心电图等 ) ,收集体检当日的随机尿样 ,测定USCN浓度。结果 USCN浓度水平为正偏态分布 ,中位数为 3 0mg/L,吸烟者USCN浓度是不吸烟者的两倍 ;白细胞 (WBC)随USCN浓度升高而增加 (P <0 0 5 ) ,血小板 (PLT)随USCN浓度升高而下降 (P <0 0 5 )。对吸烟者采用分层分析后 ,未显示USCN浓度与症状、体征以及其他健康结局有统计学联系。结论 USCN浓度与症状、体征以及其他辅助检查指标没有统计学联系。
Objective To investigate the chronic effects of cyanide on health status of workers and understand the relationship between urinary thiocyanate (CNCN) concentration and symptoms, signs and laboratory tests to verify the effectiveness of USCN as a health indicator for cyanide exposure. Methods A total of 125 cyanide workers from a petrochemical company were selected as the study subjects. The cross-sectional investigation (subjective symptoms, B-ultrasound and electrocardiogram) was performed to collect the random urine samples on the day of physical examination. The concentration of USCN was measured. Results The median concentration of USCN was positively skewed and the median was 30 mg / L. The concentration of USCN in smokers was twice as high as that in nonsmokers. WBC increased with the concentration of USCN (P <0.05) Platelets (PLT) decreased with increasing USCN concentration (P <0 05). A stratified analysis of smokers did not show a statistically significant correlation between USCN concentrations and symptoms, signs, and other health outcomes. Conclusions There is no statistical relationship between the concentration of USCN and the symptoms, signs and other auxiliary examinations.