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目的:探讨周围动脉粥样硬化闭塞症(peripheralatherosclerosisobliterans,PASO)胰岛素抵抗(Insulinresistance,IR)、内皮素(Endothelins,ET)、血管紧张素-Ⅱ(angiotension-Ⅱ,AT-Ⅱ)之间的相互关系。方法:采用特异性葡萄糖氧化酶法和放射免疫测定法对51例PASO患者进行糖耐量实验前后血糖、胰岛素(Insulin,IN)水平的测定,并计算其曲线下面积,同时采用放射免疫测定法检测血浆AT-Ⅱ和ET水平,并分别与IN及其曲线下面积作相关分析。结果:PASO患者IN、ET、AT-Ⅱ水平分别为14.79mU/L、77.69ng/L、111.33ng/L,明显高于健康对照组;同时糖负荷后1hIN及其分泌总量明显增高;糖耐量实验前后IN水平及其曲线下面积均与AT-Ⅱ、ET呈正相关系。结论:老年PASO患者存在IR现象,血管AT-Ⅱ、ET与IR之间相互影响、相互促进、共同参与PASO的形成和发展。
Objective: To investigate the relationship between Insulin resistance (IR), endothelins (ET) and angiotension-Ⅱ (AT-Ⅱ) in peripheral arterial atherosclerosis obliterans (peripheralatherosclerosisobliterans) . Methods: The blood glucose and insulin levels in 51 PASO patients before and after glucose tolerance test were measured by specific glucose oxidase and radioimmunoassay, and the area under the curve was calculated. Meanwhile, radioimmunoassay Plasma AT-II and ET levels, respectively, and IN and its area under the curve for the correlation analysis. Results: The levels of IN, ET and AT-Ⅱ in PASO patients were 14.79mU / L, 77.69ng / L and 111.33ng / L, respectively, which were significantly higher than those in healthy controls Increased; the level of IN before and after glucose tolerance test and the area under the curve were positively correlated with AT-II and ET. CONCLUSION: There is an IR phenomenon in elderly PASO patients. The interaction between blood vessel AT-II, ET and IR promotes each other and participates in the formation and development of PASO.