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目的探讨不同降糖药物对糖耐量异常(IGT)患者临床疗效、相关并发症及经济性的影响差异。方法随机数字表法将168例IGT患者分成阿卡波糖组(阿卡波糖50 mg/次,tid)、二甲双胍组(二甲双胍250 mg/次,tid)和对照组(饮食、运动调节)各56例。比较三组患者治疗前、治疗6个月后口服糖耐量试验(OGTT)结果及生活质量结果变化情况,分析其疗效、心脑血管事件及经济差异。结果治疗6个月后,三组患者空腹血糖(FPG)、服糖后2 h血糖(2 h PBG)水平均较治疗前明显降低(P<0.05),世界卫生组织生存质量测定量表简表(WHOQOL-BEFF)评估结果则较治疗前明显提高(P<0.05),且阿卡波糖组、二甲双胍组上述指标改善效果均明显优于对照组(P<0.05),但两组组间比较无统计学意义(P>0.05)。阿卡波糖组、二甲双胍组治疗有效率及治疗干预成本均明显高于对照组(P<0.05);阿卡波糖组治疗有效率与二甲双胍组比较无统计学意义(P>0.05),但治疗日成本、治疗6个月成本及成本-效益比(C/E)均明显高于二甲双胍组(P<0.05)。随访2年间,三组心脑血管事件发生率显示:二甲双胍组<阿卡波糖组<对照组,差异均有统计学意义(P<0.05)。结论阿卡波糖和二甲双胍均在IGT的临床治疗中有较高应用价值,其中二甲双胍经济性更强、对心脑血管疾病的抑制效果更突出。
Objective To investigate the effect of different antidiabetic drugs on clinical efficacy, related complications and economy in patients with impaired glucose tolerance (IGT). Methods A total of 168 patients with IGT were randomly divided into acarbose group (50 mg / acid, tid), metformin (metformin 250 mg / time, tid) and control group 56 cases. The results of oral glucose tolerance test (OGTT) and quality of life before and 6 months after treatment were compared among the three groups. The curative effect, cardiovascular and cerebrovascular events and economic differences were analyzed. Results After 6 months of treatment, fasting blood glucose (FPG) and 2 h PBG levels in the three groups were significantly lower than those before treatment (P <0.05). A summary of the World Health Organization Quality of Life Scale (WHOQOL-BEFF) was significantly higher than before treatment (P <0.05), and the acarbose and metformin groups were significantly better than the control group (P <0.05), but the difference between the two groups No statistical significance (P> 0.05). Acarbose group, metformin group and treatment intervention rate were significantly higher than the control group (P <0.05); acarbose treatment group and metformin group was no significant difference (P> 0.05), but The cost of treatment, cost of treatment for 6 months and cost-benefit ratio (C / E) were significantly higher than those of metformin group (P <0.05). The follow-up of 2 years, the incidence of cardiovascular events in three groups showed: metformin group
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