论文部分内容阅读
目的比较奥卡西平与卡马西平治疗脑卒中后继发性癫痫(PSE)的临床疗效。方法选取2014年1月—2015年1月常州市金坛区人民医院接收的PSE患者56例,按照随机数字表法分为研究组与对照组,各28例。对照组患者给予卡马西平片治疗,研究组患者给予奥卡西平治疗,比较两组患者的临床疗效、脑电图痫样放电、累及导联数及不良反应发生情况。结果研究组患者总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前两组患者脑电图痫样放电、累及导联数比较,差异无统计学意义(P>0.05);治疗后研究组患者脑电图痫样放电、累及导联数低于对照组,差异有统计学意义(P<0.05)。研究组患者不良反应率低于对照组,差异有统计学意义(P<0.05)。结论奥卡西平较卡马西平治疗PSE的临床疗效更加明显,且不良反应少。
Objective To compare the clinical efficacy of oxcarbazepine and carbamazepine in the treatment of post-stroke secondary epilepsy (PSE). Methods From January 2014 to January 2015, 56 patients with PSE received from Jintan District People’s Hospital of Changzhou were divided into study group and control group according to the random number table method, with 28 cases in each group. Patients in the control group were treated with carbamazepine, and patients in the study group were given oxcarbazepine. The clinical efficacy, EEG discharges, the number of lead involved and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of study group was higher than that of control group, the difference was statistically significant (P <0.05). There was no significant difference between the two groups before treatment (P> 0.05). After treatment, the number of EEG-induced discharges in the study group was lower than that in the control group, The difference was statistically significant (P <0.05). Adverse reaction rate in study group was lower than that in control group, the difference was statistically significant (P <0.05). Conclusion The clinical efficacy of oxcarbazepine is better than that of carbamazepine in the treatment of PSE with less adverse reactions.