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[目的 ]探讨高原低氧环境对青年战士血小板活化状态的影响。 [方法 ]对从平原 (海拔 12 0 0 m)进驻海拔 35 0 0 m、 40 0 0 m、 45 0 0 m高原 7天、 6月、 12月的 6 0名官兵进行血小板表面α-颗粒膜蛋白 (α- GMP- 140 )含量 ,血浆血栓素 B2 (TXB2 )水平 ,血小板聚集率 (PAR)等测定 ,并与 30名平原健康青年战士作对照。 [结果 ]高原战士α- GMP- 140含量 ,血浆 TXB2 和 PAR比平原战士有不同程度升高 (P<0 .0 5 ,或 P<0 .0 1) ;进驻以后 7天 ,6个月 ,12个月逐渐降低 ,进驻 12个月时α- GMP- 140 ,TXB2 和 PAR等指标较平原战士的升高无显著性 (P>0 .0 5 )。 [结论 ]健康青年战士进驻高原早期血小板高度活化 ,以后逐渐降低。因此 ,预防进驻高原后心血管疾病关键在早期预防。
[Objective] To investigate the effect of plateau hypoxic environment on platelet activation of young warrior. [Method] A total of 60 officers and men stationed at the altitude of 350 m, 40 000 m and 45 000 m on the plateau for 7 days, June and December from the plain (1200 m) (Α-GMP-140), TXB2, PAR and so on, and compared with 30 plain young healthy soldiers. [Results] The level of a-GMP-140, TXB2 and PAR in plateau soldiers increased to some extent (P <0.05 or P <0.01) 12 months, and 12 months later, the indexes of α-GMP-140, TXB2 and PAR were not significantly different from those of plain warrior (P> 0.05). [Conclusion] The healthy young soldiers stationed in Plateau early high platelet activation, then gradually decreased. Therefore, the prevention of cardiovascular disease stationed in the plateau in the early prevention.