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目的 介绍外周血造血干细胞移植在小儿恶性实体瘤治疗中的应用。方法 小儿恶性实体瘤 7例 ,男 5例 ,女 2例 ,年龄 2～ 8岁。神经母细胞瘤 5例 ,畸胎瘤 1例 ,横纹肌肉瘤 1例。在临床完全缓解或部分缓解后进行造血干细胞移植。其步骤包括外周血造血干细胞的动员和采集 ,数量及活性测定 ,保存和回输 ,预处理以及免疫辅助剂的应用。结果 7例患儿成功地完成了动员、采集、预处理和免疫重建 ,渡过了骨髓抑制期 ,最长无瘤生存期限 2 .5年。结论 外周血造血干细胞移植在小儿实体瘤治疗中具有广阔的前景 ,可以最大程度杀灭肿瘤 ,减少疗程 ,节约开支和提高生存质量
Objective To introduce the application of peripheral blood stem cell transplantation in the treatment of malignant solid tumors in children. Methods 7 cases of malignant solid tumors in children, 5 males and 2 females, aged 2 to 8 years old. Neuroblastoma in 5 cases, teratoma in 1 case, rhabdomyosarcoma in 1 case. Hematopoietic stem cell transplantation was performed after complete or partial clinical remission. The steps include the mobilization and collection of peripheral blood stem cells, the quantitative and activity determination, preservation and reinfusion, pretreatment and the use of immune adjuvants. Results Seven children successfully completed the mobilization, collection, pretreatment and immune reconstruction, survived the myelosuppression period and the longest disease-free survival period was 2.5 years. Conclusion Peripheral blood stem cell transplantation has broad prospects in the treatment of pediatric solid tumors, which can kill tumors to the greatest extent, reduce the duration of treatment, save expenses and improve the quality of life