目的探讨敏感抗生素治疗生殖道细菌感染对晚期先兆流产结局的影响。方法选取在兴国县妇幼保健院确诊为晚期先兆流产的120例孕妇为研究对象,根据是否使用抗生素治疗分为观察组(79例,按药敏试验选择敏感抗生素治疗)和对照组(41例,未使用抗生素治疗)。记录患者一般资料,进行宫颈分泌物细菌培养,同时观察治疗期间不良反应发生情况。结果两组孕妇终止妊娠孕龄、阴道分泌物检查距终止妊娠时间间距和妊娠结局比较差异有统计学意义(P<0.05);两组分娩方式、年龄分布、自然流产次数和人工流产次数比较差异无统计学意义(P>0.05);两组革兰氏阳性球菌、革兰氏阴性杆菌、真菌、支原体和沙眼衣原体分布比较差异无统计学意义(P>0.05);两组胸闷、恶心、头晕和心率增快等不良反应发生率比较差异无统计学意义(P>0.05)。结论针对感染导致的晚期先兆流产患者,应用抗生素治疗可显著改善妊娠结局,应基于微生物学检测及药物敏感试验选择相应的抗生素治疗。 Objective To investigate the effect of sensitive antibiotics in treatment of genital tract bacterial infection on the outcome of advanced threatened abortion. Methods 120 pregnant women diagnosed as threatened abortion in Xingguo County Maternal and Child Health Hospital were selected as study subjects. According to whether antibiotics were used or not, they were divided into observation group (79 cases, sensitive antibiotic treatment according to drug susceptibility test) and control group (41 cases, Not treated with antibiotics). Record the general information of patients, bacterial culture of cervical secretions, while observing the occurrence of adverse reactions during treatment. Results There were significant differences in gestational age, vaginal discharge examination time interval and pregnancy outcome between the two groups (P <0.05). There was significant difference in the mode of delivery, age, number of spontaneous abortion and the number of induced abortion (P> 0.05). There was no significant difference in the distribution of Gram-positive cocci, Gram-negative bacilli, fungi, mycoplasma and Chlamydia trachomatis between the two groups (P> 0.05) And heart rate increased adverse reactions such as the difference was not statistically significant (P> 0.05). Conclusion In patients with advanced threatened abortion due to infection, the application of antibiotic therapy can significantly improve pregnancy outcomes. The appropriate antibiotic therapy should be selected based on microbiological tests and drug susceptibility tests.