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研究了钙拮抗剂在C3H,BALB/C,C5781/6,NMRI和MAG等小鼠的不同给药途径、不同给药时间及与其它辐射防护剂合用的辐射防护特征。实验采用相当于小鼠LD_(50)一半的药物剂量来测试其辐射防护活性。~(50)Co γ射线照射,剂量率为0.9Gy/min,照射剂量一般为LD_(100)。实验表明雌雄性C3H小鼠受照10.0Gy或10.5Gy前10分钟或30分钟,腹腔注射硫氮酮110mg/kg具有辐射防护作用,照前10分钟或30分钟注射硫氮酮对小鼠30天存活率无差异,但照前120
We studied the different route of administration of Ca2 + antagonist in C3H, BALB / C, C5781 / 6, NMRI and MAG mice, different administration time and radiation protection characteristics in combination with other radioprotectants. Experiments using the equivalent of half of the mouse LD_ (50) dose of the drug to test its radiation protective activity. ~ (50) Co γ-ray irradiation, the dose rate of 0.9Gy / min, radiation dose is generally LD_ (100). Experiments show that male and female C3H mice exposed to 10.0Gy or 10.5Gy the first 10 minutes or 30 minutes, intraperitoneal injection of 110mg / kg of azithromycin has a radioprotective effect, according to the first 10 minutes or 30 minutes injection of nisin on mice The 30-day survival rate was no difference, but according to 120