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Ghrelin是一种新发现的脑肠肽,是促生长激素分泌物受体的一种内源性配体,其作用广泛,不仅能够促进生长激素的释放、增强食欲、加快胃部排空、促进胃酸分泌及食物的消化和吸收、抑制炎性细胞因子的产生、抑制心肌细胞和血管内皮细胞的凋亡,还具有调节能量代谢等作用。大量研究发现,Ghrelin与胰岛素的分泌及胰岛素抵抗存在着密切关系,同时胰岛素抵抗和β细胞功能缺陷是2型糖尿病重要的发病机制之一,本文将探讨Ghrelin在2型糖尿病的发生及发展中所起的作用。
Ghrelin, a newly discovered ghrelin, is an endogenous ligand for the growth hormone secretagogue and has a wide range of effects not only promoting the release of growth hormone, increasing appetite, accelerating gastric emptying, and promoting Gastric acid secretion and food digestion and absorption, inhibit the production of inflammatory cytokines, inhibit cardiomyocytes and vascular endothelial cell apoptosis, but also has the role of regulating energy metabolism. A large number of studies have found that Ghrelin and insulin secretion and insulin resistance are closely related, while insulin resistance and β cell dysfunction is one of the important pathogenesis of type 2 diabetes, this article will explore Ghrelin in the occurrence and development of type 2 diabetes Play a role.