先天性肥厚性幽门狭窄(CHPS)是新生儿呕吐的最常见原因之一,而其病因未明。综述其发病机制的研究进展如下:①遗传为重要因素;②平滑肌细胞神经分布异常;③幽门肌缺乏非肾上腺素能非胆碱能神经(NANC)致幽门环肌失松驰;④细胞外基质蛋白(ECM)数量异常且胶原合成活性增强,可致幽门肿块坚韧;⑤肥厚幽门环肌中IGF!I等生长因子及其受体的局部表达增加可能起重要作用。 Congenital hypertrophic pyloric stenosis (CHPS) is one of the most common causes of neonatal vomiting, and its etiology is unknown. The progress of the research on its pathogenesis is summarized as follows: (1) heredity is an important factor; (2) the neural distribution of smooth muscle cells is abnormal; (3) the pyloric muscle is deficient in non-adrenergic non-cholinergic nerve (NANC) (ECM) abnormal and collagen synthesis activity increased, can cause pyloric toughness; ⑤ hypertrophic pyloric ring muscle IGF! I and other growth factors and their receptors increased expression may play an important role.