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帕金森病是仅次于阿尔茨海默病的神经系统退行性疾病,其发病原因尚未明确,目前越来越多的研究关注小胶质细胞激活在帕金森病发病学中的作用。多种原因激活小胶质细胞后,通过炎症反应和氧化应激机制引起黑质多巴胺能神经元死亡。美满霉素、地塞米松、纳洛酮、水飞藜素以及COX-2抑制剂等可以抑制小胶质细胞的激活,保护多巴胺能神经元免受氧化应激损伤,此类抑制小胶质细胞激活的药物有可能成为帕金森病神经保护的有效药物。
Parkinson’s disease is second only to Alzheimer’s disease, neurodegenerative diseases, the etiology of the disease is not yet clear, more and more studies are concerned about microglial activation in the pathogenesis of Parkinson’s disease. A variety of reasons after activation of microglial cells, through the inflammatory response and oxidative stress mechanism caused by nigral dopaminergic neuron death. Minocycline, dexamethasone, naloxone, ephedrine and COX-2 inhibitors can inhibit microglial activation, protect dopaminergic neurons from oxidative stress, such as inhibition of microglia Cell-activated drugs are likely to be potent drugs for neuroprotection in Parkinson’s disease.