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陈皮注射剂给猫静脉注射后,可迅速而显著地改变猫的血流动力学参数,主要表现为:血压迅速上升,且脉压差增加,心输出量增加,左室内压及其最大上升速率均明显上升,而左室舒张末期压则有明显下降,心脏指数、心搏指数、每搏心输出量、左室作功指数均明显上升;而血管总外周阻力在给药后1～2min内上升,5min后则有明显下降。反映心肌氧耗指标的TTI值在给药后3min内也明显增加。上述各指标的作用时间一般在给药后瞬间至5min时,给药10min后则基本恢复或接近正常。动物的心率在给药后瞬间略有减少,其它时刻无明显改变。
After being injected intravenously into the cats, the TCM injection of cathepsin injection can rapidly and significantly change the hemodynamic parameters of cats. The main manifestations are: rapid increase of blood pressure, increase of pulse pressure difference, increase of cardiac output, left intraventricular pressure and maximum rate of increase Significantly increased, while left ventricular end-diastolic pressure was significantly decreased, heart index, heart index, stroke volume output, left ventricular work index were significantly increased; and total peripheral resistance of blood vessels increased within 1 ~ 2min after administration. After 5 minutes, there was a significant drop. The TTI value reflecting the myocardial oxygen consumption index also increased significantly within 3 minutes after administration. The action time of each of the above indicators was generally 5 minutes after administration, and it basically recovered or nearly normal after 10 minutes of administration. The heart rate of the animals was slightly reduced immediately after administration and no significant changes were observed at other times.