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目的观察比较在人工流产术前分别口服和阴道放置米索前列醇用于软化宫颈的临床效果及安全性。方法将200例妊娠45~70天,要求行人工流产术的妇女随机分成两组,试验组100例用米索前列醇0.2mg于人工流产术前4~6h置于阴道后穹隆;对照组100例于手术前4~6小时口服米索前列醇0.2mg。观察两组病例手术时宫颈软化程度、宫口大小、出血量、子宫收缩情况、人工流产综合征的发生率。结果两组妇女宫颈软化程度、子宫收缩情况、出血量、人工流产综合征的发生率均有显著性差异(P<0.05)。结论人工流产术前阴道后穹隆放置米索前列醇,能软化宫颈、扩张宫颈,其方法简便、安全,能有效减轻妇女人工流产时的痛苦,预防人工流产并发症的发生。
Objective To observe the clinical effects and safety of misoprostol orally and vaginally for cervix abortion before artificial abortion. Methods A total of 200 women with gestational age from 45 to 70 days who underwent induced abortion were randomly divided into two groups. 100 patients in the test group were treated with misoprostol 0.2 mg in the posterior vaginal vault 4 to 6 hours before artificial abortion. The control group 100 Example 4 to 6 hours before surgery oral misoprostol 0.2mg. The incidence of cervical softening, cervix size, bleeding volume, uterine contractions and abortion syndrome were observed during operation in two groups. Results The incidences of cervical softening, uterine contractions, hemorrhage and abortion syndrome in both groups were significantly different (P <0.05). Conclusions The misoprostol placed in vaginal posterior fornix before artificial abortion can soften the cervix and dilate the cervix. The method is simple and safe, which can effectively alleviate the pain of induced abortion and prevent the incidence of induced abortion.