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目的：了解护士对职业暴露的知晓与防护情况；以进一步针对性地提出补救性和预防性管理对策。方法通过自行设计的调查表对本院230名临床护士进行不记名问卷调查。结果职业暴露与防护的知晓率最高的是手卫生标准及洗手法（56.09%），最低的是医疗废物的处置方法（21.30%）；重点科室、高年资与高学历护士的职业暴露情况比非重点科室、低年资与低学历分别低43.25%、14.64%和25.53%。结论需加强临床护士对职业暴露的管理，应进一步提高相关知识培训，提高主动防护意识，加强标准预防措施制度的落实工作，减少职业暴露的发生。“,”Objective The nurse occupation exposure to understand the awareness and protection;to further put forward the remedial and Preventive Countermeasures of management.Methods By a self-designed questionnaire to the 230 clinical nurses by questionnaire investigation.Method Of the 230 clinical nurses questionnaire investigation was conducted through a questionnaire designed by ourselves. Results Occupation exposure and protection awareness is the highest rate of hand hygienestandards and washing method (56.09%), the lowest is the disposal method of medical waste material (21.30%);the key departments, senior and highly educatednurses occupation exposure than non key departments, junior and low degreerespectively 43.25%, 14.64%and 25.53%. Conclusion To strengthen the management of clinical nurses to occupation exposure, should further improve the relevant knowledge training, improve active protection consciousness, to strengthen the implementation of standard precautions systemwork, reduce the occur ence of occupation exposure.