论文部分内容阅读
目的:监测新生儿缺氧缺血性脑病(HIE)血清钙、NO、NSE、S100B的水平变化,进一步采用神经节苷脂钠干预,证实神经节苷脂钠在新生儿HIE治疗中临床应用价值及前景。方法:设对照组为非HIE患儿(无窒息、无重度感染),并依次设常规治疗组和神经节苷脂钠治疗组,采用偶氮砷终点法、硝酸还原酶法及化学放光免疫法对生后7天及不同程度HIE患儿进行血清钙、NO、NSE、S100B水平检测。结果:新生儿HIE组血清钙较对照组降低,NSE和S100B明显高于对照组,差异有统计学意义(P<0.01);与轻度组相比,中、重度HIE组血清钙含量降低,血清NO、NSE和S100B含量增高,且组间差异有统计学意义(P<0.01);经神经节苷脂钠治疗组与常规治疗组相比,神经节苷脂钠治疗后,HIE新生儿血清钙、NO、NSE和S100B较常规治疗组浓度变化明显,差异有统计学意义(P<0.01)。结论:血清NO、NSE和S100B水平在HIE发病机制中起一定作用,其水平的增高与该病的严重程度相关,可作为早期辅助诊断HIE及判定病情严重程度的可靠指标;神经节苷脂钠可降低HIE所致的脑细胞损伤,具有重要的临床价值及应用前景。
Objective: To monitor the levels of serum calcium, NO, NSE and S100B in neonates with hypoxic-ischemic encephalopathy (HIE), and to further investigate the clinical value of ganglioside sodium in neonatal HIE And prospects. Methods: The control group was non-HIE children (no asphyxia, no severe infection), followed by conventional treatment group and ganglioside sodium treatment group, azo-arsenic end-point method, nitrate reductase and chemiluminescence immunoassay Act 7 days after birth and different degrees of HIE in children with serum calcium, NO, NSE, S100B levels were detected. Results: Compared with the control group, the levels of serum calcium in neonatal HIE group were lower than those in the control group, and NSE and S100B were significantly higher than those in the control group (P <0.01) Serum NO, NSE and S100B levels increased, and the difference between the groups was statistically significant (P <0.01); ganglioside sodium treatment group compared with the conventional treatment group, ganglioside sodium treatment, HIE neonatal serum The concentrations of calcium, NO, NSE and S100B in the treatment group were significantly different (P <0.01). CONCLUSIONS: Serum levels of NO, NSE and S100B play a role in the pathogenesis of HIE. The increased levels are correlated with the severity of the disease and can be used as a reliable indicator for the early diagnosis of HIE and the severity of the disease. Ganglioside sodium Can reduce the brain injury caused by HIE, has important clinical value and application prospects.