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10年来美国密执安大学医学中心实验室和其他实验室积极地探索了肾上腺髓质的显影剂,主要是观察标记的儿茶酚胺特别是多巴胺在肾上腺髓质中的浓集情况。近年来发现~(125)碘对位-碘三甲基苯甲铵(肾上腺素神经阻断剂拟似物、溴苄铵(以下简称“化合物5”)在狗的肾上腺髓质中有浓集现象。本文报告一组~(125)碘标记溴苄铵拟似物组织学分布的初步评价(包括肾上腺髓质、肾上腺皮质、肝、肾、胆汁及甲状腺内的分布情况),这些化合物有:(1)~(125)碘邻位-碘二甲基-2-羟乙基苯甲铵,简称“化合物1”。(2)~(125)碘邻位-碘二甲基乙基苯甲铵,简称“化合物2”。(3)~(125)碘邻位-碘三甲基苯甲铵,简称“化合物3”。(4)~(125)碘对位-碘二甲基
Over the past 10 years, the University of Michigan Medical Center laboratory and other laboratories have actively explored the development of adrenal medulla, mainly to observe the concentration of labeled catecholamines, especially dopamine in the adrenal medulla. In recent years, it has been found that ~ (125) iodine para-iodotoluene (adrenergic blockade mimic, benzyl ammonium bromide (hereinafter referred to as “Compound 5”) is concentrated in the dog’s adrenal medulla This paper reports the preliminary assessment of the histological distribution of a group of ~ (125) iodobenzamidine mimics, including the distribution of adrenal medulla, adrenal cortex, liver, kidney, bile and thyroid. These compounds are: (1) ~ (125) Iodine ortho-iododimethyl-2-hydroxyethylbenzyl ammonium, abbreviated as “Compound 1.” (2) ~ (125) Iodo-iododimethylethylbenzo Ammonium, abbreviated as “Compound 2.” (3) ~ (125) Iodoterpene-iodonium trimethyl ammonium, abbreviated as “Compound 3.” (4) to (125) Iodo-iododimethyl