论文部分内容阅读
100多年前,Ringer就发现了钙离子在维持心肌收缩中具有重要作用,但其对细胞的信使功能不久前才得以明确:细胞在静息状态时,其游离钙离子浓度低于10~(-7)M,兴奋时则可增至10~(-7)～10~(-5)M之间;细胞内的钙离子受体是一种特异性的钙离子结合蛋白,其解离常数就在10~(-7)～10~(-5)M之间;在浆膜和细胞器内,具有钙离子特异的流入、流出及隔绝程序,使细胞在兴奋时钙离子浓度增高,静息时则复原.细胞内的钙离子是通过能量依赖性转运过程存在
More than 100 years ago, Ringer discovered that calcium plays an important role in maintaining myocardial contractility but its messenger function on cells was noticed only recently. When cells are resting, their free calcium concentration is less than 10% 7) M, excited to 10 ~ (-7) ~ 10 ~ (-5) M; intracellular calcium ion receptor is a specific calcium-binding protein, the dissociation constant Between 10 ~ (-7) ~ 10 ~ (-5) M; in the serosa and organelles, with calcium-specific influx, outflow and isolation procedures, so that when the cells in the excitement of calcium concentration increased at rest The recovery of intracellular calcium ions through the process of energy-dependent transport exists