肝素,即使用很大的剂量,也难于完全防止血管壁损伤部位的血栓形成。它能抑制各个时期血浆的凝固和加快纤维蛋白的溶解,但不能防止血小板和红细胞的凝集。近年来在苏联和其他的国家对吡唑酮制剂的抗凝血抗聚合特性很感兴趣。有资料表明,布塔金(苏联制剂止痛退热药,构造及作用近于安基比林,译者注)和 Heparin, even at very high doses, is difficult to completely prevent thrombus formation at the site of vascular wall injury. It inhibits plasma coagulation and fibrinolysis at various stages, but does not prevent the aggregation of platelets and erythrocytes. In recent years there has been interest in the anticoagulant anti-coagulant properties of pyrazolone formulations in the Soviet Union and other countries. Data show that Boutain (the Soviet preparation analgesic antipyretics, structure and role of nearly Ann Kimball, translator note) and