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目的 研究并比较载脂蛋白B/载脂蛋白A-I(ApoB/ApoA-I)、非高密度脂蛋白/高密度脂蛋白(NHDL-C/HDL-C)2种血清脂蛋白比值对2型糖尿病患者非糖尿病一级亲属发生代谢综合征(MS)的诊断预测价值.方法 选择来自2型糖尿病家系的非糖尿病一级亲属327例,测定身高、体质量、血压、血脂、血糖等临床和生化指标,计算 ApoB/ApoA-I、NHDL-C/HDL-C、BMI等指数.分析ApoB/ApoA-I、NHDL-C/HDL-C比值与MS各组分的相关性.ROC曲线确定两者诊断 MS 的临界值,并比较两者对2型糖尿病患者非糖尿病一级亲属发生 MS 的诊断预测效果.结果 ApoB/ApoA-I、NHDL-C/HDL-C比值随代谢综合征异常指标项数的增加而升高,且与代谢综合征各组分均明显相关.ApoB/ApoA-I、NHDL-C/HDL-C的ROC曲线下面积分别为0.743、0.822(P<0.01).结论 ApoB/ApoA-I、NHDL-C/HDL-C比值均与MS及其组分密切相关,均可单独作为MS发生发展的一个危险因素.NHDL-C/HDL-C对2型糖尿病患者非糖尿病一级亲属发生MS的预测价值优于ApoB/ApoA-I.“,”Objective To study and compare the predictive value of the two serum lipoprotein ratio:apolipoprotein B/apo-lipoprotein A-I(ApoB/ApoA-I)and non high density lipoprotein/high-density lipoprotein(NHDL-C/HDL-C),in the diagnosis of non diabetic first-degree relatives metabolic syndrome in type 2 diabetic patients.Methods We chose 327 non diabetic first-de-gree relatives from type 2 diabetes families,and measured the clinical and biochemical indexes such as height,body weight,blood pressure,blood lipid and blood sugar,and calculated indexes such as ApoB/ApoA-I,NHDL-C/HDL-C and BMI.The correlation between the ratio of ApoB/ApoA-I and NHDL-C/HDL-C and the components of MS was analyzed.The ROC curve was used to de-termine the critical value of the diagnosis of MS and to compare the predictive effect in the diagnosis of non diabetic first-degree relatives metabolic syndrome in type 2 diabetic patients.Results The ratio of ApoB/ApoA-Igna NHDL-C/HDL-C increased with the increase of abnormal items of metabolic syndrome,and was significantly related to each component of metabolic syndrome.The area under the ROC curve of ApoB/ApoA-Ig NHDL-C/HDL-C was 0.743、0.822(P<0.01).Conclusion The ratio of ApoB/ApoA-I and NHDL-C/HDL-C is closely related to MS and its components,which can be used as a risk factor for the development of MS alone.The predictive value of NHDL-C/HDL-C to MS in non diabetic first-degree relatives of type 2 diabetic patients is better than that of ApoB/ApoA-I.