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研究了１，２－二甲基－３－羟基－４－吡啶酮（ＤＨＰＯ）尿铝促排及其与维生素Ｃ（Ｖｃ）、利尿剂美司那（二巯基乙烷磺酸钠）的协同排铝作用。结果表明，ＤＨＰＯ可显著增加尿排量（Ｐ＜０．００１），ＤＨＰＯ加Ｖｃ和ＤＨＰＯ加美司那组的尿铝排量与ＤＨＰＯ组相似，但尿铝排出的峰值发生改变，组间无显著差异。
The effect of 1,2-dimethyl-3-hydroxy-4-pyridone (DHPO) on urinary aluminum excretion and its synergistic effect with vitamin C (Vc) and diuretic mesna (sodium dimercaptoethane sulfonate) Aluminum role. The results showed that DHPO significantly increased urinary output (P <0.001). DHPO plus Vc and DHPO plus megestron had similar urinary excretion of aluminum and aluminum to DHPO, but there was no significant difference between the two groups difference.