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于1994年4～12月在福州市开展学龄前儿童埃希氏大肠杆菌耐药性研究，调查了4～7岁儿童95名（男53名，女42名）用14种抗生素对分离到的87株大肠杆菌进行药敏试验。结果显示，80％以上菌株对先锋V、氯霉素、新霉素、卡那霉素、庆大霉素敏感。60％以上菌株对青霉素G、红霉素、麦迪霉素、四环素、氨苄青霉素有抗药性。多重耐药性严重，最高的抗9种药物（r＝9），耐药谱以PG、AMP、TC、EM、MD为主。导致E．Coli高耐药性的原因是滥用抗生素和不良个人卫生习惯。
From April to December 1994, a study of Escherichia coli resistance in preschool children was carried out in Fuzhou City. 95 (male 53, female 42) children aged 4 to 7 years were investigated for their resistance to 14 antibiotics 87 strains of E. coli susceptibility testing. The results showed that more than 80% of the strains of Pioneer V, chloramphenicol, neomycin, kanamycin, gentamicin sensitive. More than 60% strains of penicillin G, erythromycin, midecamycin, tetracycline, ampicillin resistance. Multi-drug resistance is serious, the highest anti-9 drugs (r = 9), resistance spectrum to PG, AMP, TC, EM, MD. Lead to E. The reason why Coli is highly resistant is the abuse of antibiotics and poor personal hygiene.