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骨髓造血微环境主要由基质细胞和细胞外基质(ECM)构成,基质细胞包括多种细胞成分,如成纤维细胞、内皮细胞、脂肪细胞、巨噬细胞等,可分泌多种造血调控因子,调节造血干、祖细胞的增殖分化和自我更新[1]。基质细胞可以合成IL6参与造血调控,已为许多学者证实[
Bone marrow hematopoietic microenvironment is mainly composed of stromal cells and extracellular matrix (ECM), stromal cells including a variety of cellular components such as fibroblasts, endothelial cells, adipocytes, macrophages, etc., can secrete a variety of hematopoietic regulatory factors, regulate Hematopoietic stem and progenitor cells proliferation and differentiation and self-renewal [1]. Stromal cells can be synthesized IL 6 involved in hematopoietic regulation, has been confirmed by many scholars [