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对经典方法不够满意、公众抱有很高期望、国际上规定不够一致,以及费用庞大,都迫使药物研究寻找新的途径。其结果,是药物化学家的专业活动正处在转变之中。一、前言:药物研究还值得进行吗? 提出这个问题,通常具有双重意义。一方面,常常认为可利用的药物品种数已经足够,而不需要新药了。另一方面,成本分析表明一个新药的发展费用极为高昂。只有少数产品能在短期内收回所需的0.5～1.5亿美元资金,从而迅速为新的研究计划提供资金。但问题是在所有疾病中仅1/3左右可以得到满意的治疗。一些常见而且危险的疾病
Unsatisfied with the classical methods, the public have high expectations, the international regulations are not consistent, and the cost is huge, forcing drug research to find new ways. As a result, the professional activities of medicinal chemists are in the process of transformation. I. Preface: Is drug research worthwhile? Having this question raised is often of dual significance. On the one hand, it is often thought that the number of available drugs is sufficient and no new drugs are needed. On the other hand, cost analysis shows the cost of developing a new drug is extremely high. Only a few products can recover the required 0.5-1.5 billion dollars in the short term, quickly funding new research programs. But the problem is that only about one-third of all diseases can be treated satisfactorily. Some common and dangerous diseases