目的 分析广东省各市首例传染性非典型肺炎病例(IAP,WHO称为SARS)的流行病学特征,为追溯传染源提供科学依据。方法 采用统一的个案调查表对广东省各市IAP首发病例进行调查,对其密切接触者也进行流行病学调查,分析各市首发病例流行病学特征、续发病例情况及各市首发病例之间的联系。结果 2002年11月16日至2003年4月16日,广东省有13个地级市报告发生(依序为佛山、河源、中山、江门、广州、深圳、肇庆、东莞、汕头、惠州、汕尾、湛江、韶关等市)。对13个市的“首发”病例进行分析:13例首发病例中,厨师和干部各有3例,农民、退休人员、工人各2例、商业人员1例;男女比例为1:0.6,年龄在18～84岁之间,30～50岁组占77％(10/13);死亡4例。2000年11月至2003年1月期间,7个市报告的首发病例中,6例为本市感染病例,1例怀疑为从广州输入病例,均无明确同类患者接触史,其中有6例引起二代或三代病例;2003年2月无新发市;2003年3月至4月16日,6市报告新发病例,2例为本市感染发病,3例感染地为香港、1例感染地为广州,5例有明确的同类患者密切接触史,只有2例引起第2代病例。结论 未发现13个首发病例间存在相互传播的线索。从13个市追溯到的可能源头集中在珠三角的6个市和香港地区。报告病例早期,由于对IAP认识不足,出现二代或三代 Objective To analyze the epidemiological characteristics of the first case of SARS in Guangdong Province (IAP, WHO called SARS), and provide a scientific basis for tracing the source of infection. Methods A case-control questionnaire was used to investigate the initial cases of IAP in Guangdong, and the epidemiological investigation of their close contacts was also conducted to analyze the epidemiological characteristics of the first cases in each city, the cases of follow-up and the links between the first cases in each city . Results From November 16, 2002 to April 16, 2003, there were 13 prefecture-level cities in Guangdong Province (in order of Foshan, Heyuan, Zhongshan, Jiangmen, Guangzhou, Shenzhen, Zhaoqing, Dongguan, Shantou, Huizhou and Shanwei , Zhanjiang, Shaoguan and other cities). In the first episode of 13 cases, there were 3 chefs and cadres, 2 peasants, 2 retirees, 1 worker and 1 commercial worker respectively. The male / female ratio was 1: 0.6, the average age was Between 18 to 84 years old, 30 to 50 years old group accounted for 77% (10/13); 4 died. Between November 2000 and January 2003, of the seven first reported cases in the seven municipalities, 6 were city-based and 1 was suspected of being imported from Guangzhou. There was no clear history of exposure to this group of patients, of which 6 were caused Second or third generation cases; no new onset in February 2003; newly emerging cases in six cities from March to April 2003, two cases of infection in the city, three cases of infection in Hong Kong and one case of infection To Guangzhou, 5 patients had a clear history of close contact with similar patients, only 2 cases caused the second generation of cases. Conclusion No clues were found to be found among 13 first cases. Possible sources dating back to 13 cities are concentrated in 6 cities in the Pearl River Delta and Hong Kong. Early in the reporting case, due to lack of awareness of IAP, there are two or three generations