目的综合分析阿替普酶在急性脑梗死治疗中的应用效果。方法 50例急性脑梗死患者,随机分为观察组与对照组,各25例。观察组采用阿替普酶静脉溶栓治疗,对照组采用非静脉溶栓治疗。比较两组的治疗效果。结果观察组总有效率92.0%高于对照组68.0%,差异具有统计学意义(P<0.05);治疗后5 h、22 h、12 d观察组美国国立卫生院神经功能缺损评分(NIHSS)(11.2±4.5)、(8.4±3.6)、(4.6±2.1)分显著优于对照组(14.9±4.4)、(12.1±3.7)、(10.1±2.3)分,差异具有统计学意义(P<0.05)。结论采用阿替普酶静脉溶栓治疗急性脑梗死患者相比采用非静脉溶栓治疗效果更理想。 Objective To analyze the effect of alteplase in the treatment of acute cerebral infarction. Methods Fifty patients with acute cerebral infarction were randomly divided into observation group and control group, with 25 cases in each group. The observation group was treated with intravenous alteplase and the control group with non-intravenous thrombolysis. Compare the treatment effect of two groups. Results The total effective rate in the observation group was 92.0%, which was significantly higher than that in the control group (68.0%), the difference was statistically significant (P <0.05). After the treatment, the neurological deficit score (NIHSS) 11.2 ± 4.5), (8.4 ± 3.6) and (4.6 ± 2.1) were significantly better than those in the control group (14.9 ± 4.4), (12.1 ± 3.7) and (10.1 ± 2.3), respectively ). Conclusion Intravenous thrombolytic therapy with alteplase in patients with acute cerebral infarction compared with non-intravenous thrombolytic therapy is more effective.