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目的分析我院儿童乙肝疫苗免疫效果,为乙肝疫苗加强接种策略提供依据。方法对我院2009年3月至2011年12月接种基础乙肝疫苗全程的821例儿童,采用ELISA法查乙肝5项标志物,同时用电化学发光法(ECLA)对乙肝表面抗体(抗-HBs)进行定量分析。结果随年龄增长,儿童抗-HBs含量和抗-HBs阳性率随之下降。结论乙肝疫苗免疫效果随免疫年限的增长而减弱,需要及时加强免疫。
Objective To analyze the immunization effect of hepatitis B vaccine in children in our hospital and provide evidence for strengthening the vaccination strategy of hepatitis B vaccine. Methods A total of 821 children who received basic hepatitis B vaccine from March 2009 to December 2011 in our hospital were enrolled in the study. Five markers of hepatitis B were detected by ELISA, and the anti-HBs antibodies (anti-HBs ) For quantitative analysis. Results With age, children anti-HBs content and anti-HBs positive rate decreased. Conclusion The immune effect of hepatitis B vaccine is weakened with the increase of the immunization duration, which needs to be strengthened in time.