目的分析子痫前期与2个血栓形成基因单核苷酸多态性——凝血因子VG1691A和凝血因子IIG20210A之间的关系。方法使用Pubmed和Embase系统搜索2015年11月前相关文献,搜索关键词包括:子痫前期、血栓形成、凝血因子V Leiden、凝血酶原基因20 210及其之间不同排列组合。对入选文献进行Meta分析。结果共有37项研究中的5 048名重度子痫前期患者和6 796名健康对照者被纳入Meta分析中。结果显示凝血酶原G20210A基因多态性与所有类型子痫前期风险增加有关,而与重度子痫前期关联尤为密切。凝血因子V突变与所有类型子痫前期风险增加有关,而与重度子痫前期关联尤为密切。结论凝血因子VG1691A和凝血因子IIG20210A单核苷酸多态性与所有类型子痫前期和重度子痫前期风险增加有关。 Objective To analyze the relationship between preeclampsia and two single nucleotide polymorphisms of thrombosis-coagulation factor VG1691A and coagulation factor IIG20210A. Methods The Pubmed and Embase systems were used to search for relevant articles before November 2015. The search terms include: preeclampsia, thrombosis, coagulation factor V Leiden, prothrombin 20 20 210 and their permutations in different combinations. Meta-analysis of selected documents. Results A total of 5048 patients with severe preeclampsia and 6796 healthy controls in 37 studies were included in the meta-analysis. The results showed that the prothrombin G20210A polymorphism was associated with an increased risk of all types of preeclampsia and was more closely associated with severe preeclampsia. Clotting factor V mutations are associated with an increased risk of all types of preeclampsia and are more closely associated with severe preeclampsia. Conclusion The single nucleotide polymorphisms of coagulation factor VG1691A and coagulation factor IIG20210A are associated with an increased risk of all types of preeclampsia and severe preeclampsia.