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乙型肝炎病毒ＨＢｅＡｇ阴性变异株的出现及演变涉及病毒突变和选择条件两个方面［１］，目前造成ＨＢＶ突变的免疫因素尚未阐明。抗ＨＢｅ特异免疫应答主要由分泌不同细胞因子的ＣＤ４＋Ｔ辅助细胞（ＴＨ）亚群调节［２，３］，为分析不同亚群在ＨＢＶ突变中的作用，对不同?
The occurrence and evolution of hepatitis B virus HBeAg-negative mutant strains involve two aspects of virus mutation and selection [1]. The current immune factors that cause HBV mutation have not been elucidated yet. Anti- HBe-specific immune response is mainly regulated by subsets of CD4 + T helper cells (TH) secreting different cytokines [2,3]. To analyze the role of different subsets in HBV mutation,