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目的:研究DA受体与左旋四氢巴马汀(l-THP)镇痛作用的关系,以阐明l-THP的镇痛机制。方法:腹腔(ip)与鞘内(ith)给药,以大鼠甩尾反应观测热伤害性致痛阈。结果:ip l-THP或D_2受体拮抗剂螺哌隆产生剂量依赖性镇痛效应,并能被D_2受体激动剂喹吡罗翻转,但不被纳洛酮翻转。而ithl-THP或螺哌隆无镇痛效应,但它们能拮抗ith喹吡罗引起的镇痛效应。结论:激动脊髓D_2受体或阻滞脊髓以上水平D_2受体均产生镇痛效应;l-THP镇痛作用通过阻滞脊髓以上D_2受体实现。
OBJECTIVE: To study the analgesic effect of DA receptor and L-THP to elucidate the analgesic mechanism of l-THP. Methods: Intraperitoneal (ip) and intrathecal (ith) administration were used to observe the thermal nociceptive pain threshold in rat tail flick reaction. RESULTS: Spiperone, an ip l-THP or D 2 receptor antagonist, produced a dose-dependent analgesic effect and was overturned by the quinone D 2 receptor agonist quinpirole, but not reversed by naloxone. However, ithl-THP or spiperone had no analgesic effect, but they were able to antagonize the analgesic effect caused by ith quinopril. CONCLUSION: The analgesic effect is induced by stimulating D_2 receptors in the spinal cord or blocking D_2 receptors above the level of the spinal cord. The analgesic effect of l-THP is achieved by blocking D_2 receptors above the spinal cord.