Rokitansky氏1842年创用“急性黄色肝萎缩”一词。Zenker氏1872年观察“红色肝萎缩”为黄色肝萎缩的后随阶段。Herxheimer氏1923年最早使用“急性肝环死”一词。Frerichs氏1879年及Cayley氏1883年较早认识亚急性黄色肝萎缩。急性及亚急性黄色肝萎缩在过去认为是少见的疾病,自从传染性肝炎广泛流行,若干肝毒性 Rokitansky created the word “acute yellow liver atrophy” in 1842. Zenker’s observation in 1872 that “red liver atrophy” is a late stage of yellow liver atrophy. Herxheimer’s first use of the word “acute liver cirrhosis” in 1923. Frerichs’s 1879 and Cayley’s 1883 earlier recognized subacute yellow liver atrophy. Acute and subacute yellow liver atrophy was a rare disease in the past, and since the widespread epidemic of infectious hepatitis, several hepatotoxicities