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用编码病毒复制酶的基因转化植物能赋予植物对病毒的高度抗病性。利用病毒的复制酶基因已经成功地获得对烟草花叶病毒（ＴＭＶ）、黄瓜花叶病毒（ＣＭＶ）、马铃薯Ｘ病毒（ＰＶＸ）、马铃薯Ｙ病毒（ＰＶＹ）等具有高度抗病性的转基因植物。复制酶基因在ＲＮＡ水平或者蛋白质水平上的表达，干扰了复制酶的正常功能，进而有效地抑制了病毒的复制，从而达到抗病的目的。
Plant transformation with a gene encoding a viral replicase confers a plant a high degree of resistance to the virus. Transgenic plants that are highly resistant to Tobacco mosaic virus (TMV), cucumber mosaic virus (CMV), potato X virus (PVX), potato virus Y (PVY) and the like have been successfully obtained using the replicase gene of the virus. Replicase gene expression at the RNA level or protein level, interfere with the normal function of the replicase, and thus effectively inhibit the virus replication, so as to achieve the purpose of resistance.