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本研究对69例皮下埋植避孕者根据阴道出血类型不同分为月经规则组、月经紊乱组、闭经组,并对其分别进行生殖激素测定,监测卵泡生长发育及宫颈评分。结果表明:埋植期间月经规则组除黄体期P水平较正常对照组降低外(P<0.01),其它生殖激素均在正常范围内波动;月经紊乱组及闭经组P和E2低于正常对照组黄体期,相当于正常对照组卵泡期低水平。B超监测卵泡表现三种类型:1.卵泡逐渐成熟并排卵;2.卵泡逐渐长大并在整个周期内持续存在;3.卵泡未发育。研究结果提示黄体功能不足是皮下埋植避孕的作用机理之一,并说明皮下埋植者月经失调和生殖激素及卵泡发育特征之间的变化与LNG的抑制有关,研究结果进一步证实皮下埋植剂具有高效、安全的优点,对扩大推广应用皮下埋植避孕法起到指导作用。
In this study, 69 cases of subcutaneously implanted contraceptives were divided into menstrual rule group, menstrual disorder group and amenorrhea group according to the types of vaginal bleeding. The reproductive hormones were measured respectively to monitor the follicular growth and cervical score. The results showed that the menstrual regular group except the luteinizing phase during the implantation period was lower than the normal control group (P <0.01), other reproductive hormones fluctuated within the normal range; the menstrual disorders and amenorrhea group, P and E2 were lower than normal The control group luteal phase, equivalent to the normal control group low level of follicular phase. B-monitoring of follicular manifestations of three types: 1. Follicles gradually mature and ovulate; 2. Follicles gradually grow and persist throughout the cycle; 3. Follicles are not developing. The results suggest that luteal insufficiency is one of the mechanism of subcutaneous implant contraceptives, and shows that subcutaneous implants, menstrual disorders and reproductive hormones and follicular development characteristics and changes in LNG inhibition, the results further confirmed subcutaneous implants Has the advantages of high efficiency and safety, and plays a guiding role in expanding and popularizing the subcutaneous implantation contraceptive method.