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目的观察复方甘草酸苷对慢性肾脏疾病蛋白尿和肾功能的影响。方法38例慢性肾脏疾病患者随机分为2组,对照组:按常规的慢性肾脏疾病治疗并根据患者的具体情况采用抗炎、低蛋白饮食、抗凝和降脂治疗。治疗组:在对照组治疗的基础上加用复方甘草酸苷注射液(美能)60ml加入5%葡萄糖300ml中静脉滴注,糖尿病患者加入适量胰岛素,1日1次,共治疗4周观察蛋白尿和肾功能的变化。结果治疗组24h尿蛋白(pro)尿素氮(Bun)、血清肌酐(Cr)明显降低,与对照组比较,差异有显著性(P<0.05)。结论复方甘草酸苷对慢性肾脏疾病有保护作用,可减少尿蛋白的排泄,改善肾功能,且无明显不良反应。
Objective To observe the effects of compound glycyrrhizin on proteinuria and renal function in patients with chronic kidney disease. Methods Thirty-eight patients with chronic kidney disease were randomly divided into two groups. The control group was treated with conventional chronic kidney disease and anti-inflammatory, low-protein diet, anticoagulant and lipid-lowering therapy according to the patients’ specific conditions. Treatment group: On the basis of the treatment of the control group, compound glycyrrhizin injection (Mei Neng) 60ml was added to 5% dextrose 300ml for intravenous infusion. Diabetic patients were given appropriate amount of insulin once a day for 4 weeks to observe the proteinuria And changes in renal function. Results The levels of serum urea nitrogen (BUN) and serum creatinine (Cr) in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion Compound glycyrrhizin has a protective effect on chronic kidney disease, can reduce urinary protein excretion, improve renal function, and no obvious adverse reactions.