在制备栓剂时,为使栓剂中药品含量准确,通常需按药品置换价计算栓剂基质的用量,这在一般药剂学教科书中都有论述。问题是,文献中所列置换价通常是指与柯柯豆脂1g 所占体积相等的药品的克数,而我国目前所用的栓剂基质却不是柯柯豆脂,而是各种代用品(如半合成脂肪酸酯等),计算栓剂基质用量时,常苦于没有对于各种基质代用品的置换价数据。为此,可对于选定的栓剂基质, In preparing suppositories, it is common to calculate the amount of suppository base at the drug replacement price for accurate suppository content as discussed in the textbook of general pharmaceutics. The problem is that the replacement price listed in the literature usually refers to grams of the equivalent volume of Coke soyabean 1g, and the suppository matrix used in our country is not Coke soy but instead of various substitutes Semi-synthetic fatty acid esters, etc.), calculate suppository base dosage, often suffer from no replacement price data for a variety of matrix substitutes. For this purpose, the suppository base selected,