目的　探讨尿激酶型纤溶酶原激活剂 (uPA)和血管内皮细胞生长因子 (VEGF)在人脑星形细胞瘤中的表达特征及意义。方法　用免疫组化的方法检测uPA和VEGF在 6 4例星形细胞瘤、4例垂体腺瘤、5例正常脑组织中的表达情况。结果　 6 4例星形细胞瘤中均有uPA和VEGF的表达 ,且随恶性程度的升高 ,其表达也随之升高。在垂体腺瘤中低度表达 ,在正常脑组织中无表达。uPA和VEGF在星形细胞瘤中的表达呈正相关 (r =0 .92 )。结论　uPA和VEGF的表达与星形细胞瘤的侵袭性和血管的生成等有关。uPA和VEGF在星形细胞瘤中的表达具有协同性 Objective To investigate the expression and significance of urokinase-type plasminogen activator (uPA) and vascular endothelial growth factor (VEGF) in human brain astrocytoma. Methods The expression of uPA and VEGF in 64 cases of astrocytoma, 4 cases of pituitary adenoma and 5 cases of normal brain tissue were detected by immunohistochemistry. Results The expression of uPA and VEGF in 64 astrocytomas both increased with the increase of malignant degree. Low expression in pituitary adenomas, no expression in normal brain tissue. The expression of uPA and VEGF in astrocytoma was positively correlated (r = 0.92). Conclusion The expression of uPA and VEGF is related to the invasion of astrocytomas and the formation of blood vessels. Expression of uPA and VEGF in astrocytomas is synergistic