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目的建立实验性糖尿病肾病(DN)动物模型,研究芪药消渴胶囊治疗DN的作用。方法 SD大鼠用高糖高脂饲料喂养合并单侧肾切除、配合一次性腹腔注射40 mg/kg链脲佐菌素制造糖尿病肾病模型,芪药消渴胶囊2.4、1.2、0.6 g/kg灌胃治疗12 W,期间观察动物体重、饮水、饮食量、血糖变化,12 W时取血检测糖化血红蛋白(HbAlc)。结果 DN模型大鼠出现三多一少症状,各给药组均能改善此种状态,芪药消渴胶囊各剂量组灌胃给药12 W均能不同程度抑制DN模型大鼠HbAlc的增加。结论芪药消渴胶囊可改善糖尿病大鼠肾功能,对肾功能损伤有一定的治疗作用。
Objective To establish an animal model of experimental diabetic nephropathy (DN) and study the effect of Qi Yao Xiaoke Capsule in treating DN. Methods SD rats were fed with high-fat and high-fat diet combined with unilateral nephrectomy. One-time intraperitoneal injection of streptozotocin (40 mg / kg) was used to make a diabetic nephropathy model. Stilbene Capsules 2.4, 1.2, 0.6 g / The stomach was treated for 12 weeks. The body weight, water intake, food intake and blood glucose level were observed during the period of treatment. HbA1c levels were measured at 12 W. Results In DN model rats, more than three symptoms and one less symptom appeared. Each administration group could improve this state. Each dose group of QLXXD group could inhibit the increase of HbAlc in DN rats with different degrees. Conclusion: Qixiaoxiaoke Capsule can improve renal function of diabetic rats and have certain therapeutic effect on renal dysfunction.