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目的探讨慢性肝炎患者血清中结缔组织生长因子(CTGF)、血小板衍生生长因子-BB(PDGF-BB)以及可溶性细胞黏附分子-1(sICAM-1)在肝纤维化诊断中的临床价值。方法用ELISA法检测192例慢性肝炎患者血清中CTGF、PDGF-BB以及sICAM-1,并与肝穿刺病理检查结果进行相关性分析;用ROC曲线评估这些指标在肝纤维化诊断中的价值。结果血清CTGF、PDGF-BB、sICAM-1均与肝纤维化分期呈正相关,ROC曲线下面积(AUC)分别为0.817、0.765、0.733;联合CTGF、PDGF-BB以及sICAM-1可以明显提高诊断的准确性。结论血清CTGF、PDGF-BB、sICAM-1是预测肝纤维化分期较好的标记物,在肝纤维化程度评价中有较高的应用价值。
Objective To investigate the clinical value of serum CTGF, PDGF-BB and sICAM-1 in the diagnosis of hepatic fibrosis in patients with chronic hepatitis. Methods The serum levels of CTGF, PDGF-BB and sICAM-1 in 192 patients with chronic hepatitis were detected by ELISA. The correlations between CTGF, sICAM-1 and pathological results of liver biopsy were analyzed. The ROC curve was used to evaluate the value of these markers in the diagnosis of liver fibrosis. Results The serum CTGF, PDGF-BB and sICAM-1 levels were positively correlated with the stage of liver fibrosis. The area under the curve of ROC (AUC) were 0.817, 0.765 and 0.733, respectively. Combined with CTGF, PDGF-BB and sICAM- accuracy. Conclusions Serum CTGF, PDGF-BB and sICAM-1 are good markers for predicting the stage of liver fibrosis, and have a high value in the evaluation of the degree of liver fibrosis.