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目的:观察早期肠内营养(EEN)支持对重型颅脑外伤病人肺部感染的预防疗效。方法:选择青壮年重型颅脑外伤60例,随机分为EEN组和对照组。EEN组在伤后或术后12～24 h内给予EN,对照组在伤后或术后24 h～5 d给予EN,利用双糖试验法测定两组病人的肠黏膜屏障功能,观察病人肺部感染发生时间等临床指标。结果:EEN组病人伤后第7天乳果糖/甘露醇比值明显低于对照组,病人平均体温、肺部感染发生率也低于对照组,按照ADL评分法,EEN组病人的恢复期日常行为能力明显好于对照组。结论:EEN可改善重型颅脑外伤病人的肠黏膜屏障功能,减少肺部感染的发生率,有利于病人的康复。
Objective: To observe the prevention and treatment effect of early enteral nutrition (EEN) on pulmonary infection in patients with severe traumatic brain injury. Methods: 60 young patients with severe traumatic brain injury were selected and randomly divided into EEN group and control group. EN was given to the EEN group within 12-24 hours after injury or EN was given to the control group 24 hours to 5 days after injury or postoperatively. The intestinal mucosal barrier function was measured by the disaccharide test in both groups. Department of infection and other clinical indicators of time. Results: The ratio of lactulose / mannitol in EEN group was significantly lower than that in control group on the 7th day after injury. The average body temperature and the incidence of pulmonary infection in patients in EEN group were also lower than those in control group. According to ADL score, Ability was significantly better than the control group. Conclusion: EEN can improve intestinal mucosal barrier function in patients with severe craniocerebral trauma and reduce the incidence of pulmonary infection, which is benefit to the patient’s recovery.